Sao Tome and Principe is a Least Developed Country (LDC) as well as a Small Island Developing State (SIDS), with a fragile and externally dependent economy and high poverty rates. The country witnessed an epidemiological transition, with a double burden of communicable and non-communicable diseases that coexist with high burden of neonatal disorders. Sao Tome and Principe faced issues with good quality data collection, validation, and decision-making due to the lack of a single health information system meeting international standards. To address this structural weakness, the Ministry of Health (MoH) of Sao Tome and Principe decided to officially adopt and expand the District Health Information Software (DHIS2) platform, a free, open-source software platform for collecting, analyzing, visualizing and sharing data. World Health Organization (WHO) and United Nations Development Programme (UNDP) provided technical and operational support to the government of Sao Tome and Principe on the launch of DHIS2 to monitor access to health services for all, and particularly for the most vulnerable people.