To address growing energy demands while reducing its environmental impact, Johnson & Johnson Xi’an constructed a state-of-the-art manufacturing site. To meet and surpass its LEED Gold® certification, it implemented a series of Fourth Industrial Revolution technologies, including AI algorithms for process control, IIoT-based intelligent cleaning and digital twins. This has resulted in a 47% reduction in material waste, a 26% decrease in GHG emissions and a 23% reduction in energy consumption.